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Microdosing GLP-1: Symptoms and Tolerability



What it is:

Glucagon-like peptide-1 (GLP-1) is a naturally occurring hormone in the gut crucial in regulating insulin secretion, hunger, and food intake. GLP-1 is our natural signal of fullness or satiety. Certain weight-loss medications mimic this process, offering a potential solution for those struggling with weight management and metabolic health.


Recently, the concept of "microdosing" GLP-1 agonist medications has garnered attention due to its approach of using smaller-than-prescribed doses of medication. Reasons vary, but reducing the dose may decrease side effects, increase tolerability, or other personalized response decisions.



What the science says:

Beyond weight loss, GLP-1 medications have shown promise in offering a variety of health benefits, such as:

  • Reduced overall inflammation

  • Appetite reduction: Limiting reliance on ultra-processed foods, sugar-sweetened items, and other non-nutritious substances.

  • Better management of blood sugar levels and cholesterol


However, these benefits aren’t without trade-offs. Potential risks may include:

  • Muscle loss, particularly if protein intake and resistance training aren't prioritized during weight loss

  • Possible increased risk of certain cancers

  • Unknown long-term effects, especially with newer medications


GLP-1 medications can have adverse side effects, such as:

  • Nausea, diarrhea, constipation, vomiting, abdominal pain

  • Fatigue, headache, dizziness, lethargy

  • Injection site reactions, and gastroenteritis.


By using lower doses, individuals may experience fewer or less intense side effects, improving tolerability and therefore adherence to treatment. However, the effectiveness of microdosing compared to standard dosing remains unclear, and requires further research. Speaking with your doctor about any issues or concerns you’re having rather than adjusting the dosage yourself is the best approach to these medications.


However, there are natural ways to support your body’s own GLP-1 production. Adjusting eating habits and lifestyle changes may increase your GLP-1 levels. Natural GLP-1 stimulators include:

  • Whole foods - rich in protein, healthy fats, and fiber:

    • Eggs, nuts, seeds, whole grains, olive oil, and avocados.

  • Dark Greens - rich in thylakoids

    • Spinach, kale, broccoli, swiss chard

    • Herbs - Parsley and dill

    • Seaweed (Uva or Sea lettuce)

  • Supplements:


Additionally, practices like regular physical activity, high-quality sleep, and stress management have been shown to boost natural GLP-1 levels. These habits should be the foundation of any health regimen, whether or not you choose to use medications.


If you choose to take GLP-1 medications we strongly recommend that they are prescribed and carefully monitored by your physician. A significant risk with microdosing is incorrectly administering the medication. If you desire to learn more, we can refer you to nationally renowned medical weight loss specialist, Dr. Eden Miller, who can provide a virtual consultation, prescription, and regular monitoring.


References and Resources:


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